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Aggressive variants of follicular cell derived thyroid carcinoma; the so called 'Real Thyroid Carcinomas' 17 Aug 2013 | 11:22 am
The pathological diagnoses and classification schemes for thyroid carcinoma have changed over the past 20 years and continue to do so. New entities have been described and molecular analyses have sugg...
EGFR mutant-specific immunohistochemistry has high specificity and sensitivity for detecting targeted activating EGFR mutations in lung adenocarcinoma 17 Aug 2013 | 11:22 am
Aim We assessed the diagnostic accuracy of epidermal growth factor receptor (EGFR) mutant-specific antibodies for detecting two common activating EGFR mutations. Methods Immunohistochemical express...
T-cell clonality is detected in a high frequency among patients with incidental lymphocytosis by PCR assays for TCR gene rearrangements 17 Aug 2013 | 11:22 am
Aims Clonal expansion of lymphocytes may account for asymptomatic lymphocytosis. Unlike monoclonal B lymphocytosis, the detection of T-cell clones is difficult using immunophenotype-based assays. Thi...
Clinico-pathological characteristics and clinical outcome of different histological types of pancreatic cancer in a large Middle European series 17 Aug 2013 | 11:22 am
Aims Pancreatic cancer (PC) is a heterogeneous disease in terms of histological and molecular subtypes. The aim of this study was to evaluate the prognostic impact of different histological subtypes ...
Correlation between the expression of Id-1 and hyperthermia-associated molecules in oral squamous cell carcinoma 17 Aug 2013 | 11:22 am
Objective To investigate the expression of inhibitor of differentiation/DNA binding (Id-1), phosphatidylinositol-3-kinase/protein kinase B pathway proteins and hyperthermia-associated protein and the...
PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome 17 Aug 2013 | 11:22 am
Aims Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable ...
Osteoid osteoma and osteoblastoma: novel histological and immunohistochemical observations as evidence for a single entity 17 Aug 2013 | 11:22 am
Aims Osteoid osteoma and osteoblastoma have, in the past, been variously regarded as both similar and distinct entities. Currently, WHO classifies these tumours separately. We compared archetypal cas...
Circulating cell-free DNA in serum as a biomarker of colorectal cancer 17 Aug 2013 | 11:22 am
Aims The aim of this study was to report circulating cell-free DNA using ALU247 and ALU247/ALU115 biomarkers in serum of operated and non-operated patients with colorectal cancer (CRC). Methods To ...
Diagnostic utility of androgen receptor expression in discriminating poorly differentiated urothelial and prostate carcinoma 17 Aug 2013 | 11:22 am
Aims Pathological separation of poorly differentiated urothelial and prostate carcinoma is difficult, but imperative because of the impact on patient management. Tumour morphology, in conjunction wit...
Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina 17 Aug 2013 | 11:22 am
Background Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary athe...
