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Optimal Vitamin D Status: A Critical Analysis on the Basis of Evidence-Based Medicine 6 Aug 2013 | 10:01 pm
Context: Public health authorities around the world recommend widely variable supplementation strategies for adults, whereas several professional organizations, including The Endocrine Society, recom...
Upregulated miR-155 in Papillary Thyroid Carcinoma Promotes Tumor Growth by Targeting APC and Activating Wnt/{beta}-Catenin Signaling 6 Aug 2013 | 10:01 pm
Context: MicroRNAs (miRNAs) are strongly implicated in many cancers, including papillary thyroid carcinoma (PTC), which is the most common malignancy in thyroid tissue. Recently, miRNA-155 (miR-155) ...
Development of p21 Activated Kinase-Targeted Multikinase Inhibitors That Inhibit Thyroid Cancer Cell Migration 6 Aug 2013 | 10:01 pm
Context: The p21 activated kinases (PAKs) are a family of serine/threonine kinases that are downstream effectors of small GTPase Cdc42 and Rac. PAKs regulate cell motility, proliferation, and cytoske...
The Rise of Soluble TWEAK Levels in Severely Obese Subjects After Bariatric Surgery May Affect Adipocyte-Cytokine Production Induced by TNF{alpha} 6 Aug 2013 | 10:01 pm
Context: Soluble TNF-like weak inducer of apoptosis (sTWEAK) is generated by the intracellular proteolytic cleavage of full-length membrane-bound TNF-like weak inducer of apoptosis (mTWEAK). sTWEAK l...
Down-Regulation of miR-218-2 and Its Host Gene SLIT3 Cooperate to Promote Invasion and Progression of Thyroid Cancer 6 Aug 2013 | 10:01 pm
Context: The functional relationships between intronic microRNAs (miRNAs) and their host genes in thyroid cancer remain unclear. miR-218, a miRNA down-regulated in several kinds of cancers and associ...
Inhibition of Parathyroid Hormone Secretion by Caffeine in Human Parathyroid Cells 6 Aug 2013 | 10:01 pm
Context and Objective: Caffeine is a highly consumed psychoactive substance present in our daily drinks. Independent studies have reported associations between caffeine consumption, low bone mineral ...
Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Stud... 6 Aug 2013 | 10:01 pm
Background and Aims: High-density lipoproteins (HDLs) may directly stimulate β-cell function and glucose metabolism. We determined the relationships of fasting high-density lipoprotein cholesterol (H...
Adipose Tissue Collagen and Inflammation in Nonobese Asian Indian Men 6 Aug 2013 | 10:01 pm
Objective: Obesity is thought to be the driving force for activation of adipose tissue (AT) collagen production and inflammation as well as systemic insulin resistance. The objective of this study wa...
Relationship Between Serum Polyunsaturated Fatty Acids and Pregnancy in Women Undergoing In Vitro Fertilization 6 Aug 2013 | 10:01 pm
Context: Polyunsaturated fatty acids (PUFAs) and their metabolism may be important in normal reproductive function and fertility. Associations between physiologic PUFAs and pregnancy have not been es...
Plasma Levels of Advanced Glycation Endproducts N{epsilon}-(carboxymethyl)lysine, N{epsilon}-(carboxyethyl)lysine, and Pentosidine Are not Independent... 6 Aug 2013 | 10:01 pm
Objective: Experimental and histological data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, the epidemiol...