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Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN-{gamma}+CD4+ T Cell Numbers during Colitis Development in Mice [MUCOSAL IMMUNOLOGY] 21 Aug 2013 | 01:02 am
The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells) modulates both immune responses and autoimmune disease severity. However, the peritoneal cavity also conta...
Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell-Mediated Colitis [MUCOSAL IMM... 21 Aug 2013 | 01:02 am
We explored the function of endogenous type I IFNs (IFN-1) in the colon using the T cell adoptive transfer model of colitis. Colon mononuclear phagocytes (MPs) constitutively produced IFN-1 in a Toll/...
Activation of p38{alpha} in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections [MUCOSAL IMMUNOLOGY] 21 Aug 2013 | 01:02 am
Intestinal infections by attaching and effacing (A/E) bacterial pathogens cause severe colitis and bloody diarrhea. Although p38α in intestinal epithelial cells (IEC) plays an important role in promot...
Proinflammatory V{delta}2+ T Cells Populate the Human Intestinal Mucosa and Enhance IFN-{gamma} Production by Colonic {alpha}{beta} T Cells [MUCOSAL I... 21 Aug 2013 | 01:02 am
In nonhuman primates, V9V2+ (V2)T cells proliferate and accumulate in mucosal tissues following microbial activation. Human V2T cells produce proinflammatory cytokines in response to bacterial species...
Vinculin Arrests Motile B Cells by Stabilizing Integrin Clustering at the Immune Synapse [MOLECULAR AND STRUCTURAL IMMUNOLOGY] 21 Aug 2013 | 01:02 am
Lymphocytes use integrin-based platforms to move and adhere firmly to the surface of other cells. The molecular mechanisms governing lymphocyte adhesion dynamics are however poorly understood. In this...
Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normal and Asthmatic Airway Smooth Muscle Cell Migration [MOLECULAR AND STRUCT... 21 Aug 2013 | 01:02 am
Structural cell migration plays a central role in the pathophysiology of several diseases, including asthma. Previously, we established that IL-17–induced (CXCL1, CXCL2, and CXCL3) production promoted...
Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice [INNATE IMMUNITY AND INFLAMMATION] 21 Aug 2013 | 01:02 am
The roles of IL-1R–associated kinase (IRAK)2 and IRAK1 in cytokine production were investigated using immune cells from knock-in mice expressing the TNFR-associated factor 6 (TRAF6) binding-defective ...
Amplified NKG2C+ NK Cells in Cytomegalovirus (CMV) Infection Preferentially Express Killer Cell Ig-like Receptor 2DL: Functional Impact in Controlling... 21 Aug 2013 | 01:02 am
CMV infection represents a major complication in hematopoietic stem cell transplantation, which compromises graft outcome. Downregulation of HLA class I expression is one mechanism by which CMV evades...
NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity [INNATE IMMUNITY AND INF... 21 Aug 2013 | 01:02 am
Whereas neutrophil elastase, cathepsin G, and proteinase 3 have been known as granule-associated serine proteases of neutrophils for decades, a fourth member, called neutrophil serine protease 4 (NSP4...
Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation [INNATE IMMUNITY AND INFLAMMATION] 21 Aug 2013 | 01:02 am
Persistent activation of NF-B has been associated with the development of asthma. Receptor-interacting protein 2 (Rip2) is a transcriptional product of NF-B activation. It is an adaptor protein with s...
