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What can plants do for cell biology? 14 Aug 2013 | 12:00 am
Historically, cell biologists studied organisms that represented a reasonable sampling of life's diversity, whereas recently research has narrowed into a few model systems. As a result, the cells of p...
Amyloid-{beta} oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons 14 Aug 2013 | 12:00 am
Disruption of fast axonal transport (FAT) is an early pathological event in Alzheimer's disease (AD). Soluble amyloid-β oligomers (AβOs), increasingly recognized as proximal neurotoxins in AD, impair ...
RanGTP and CLASP1 cooperate to position the mitotic spindle 14 Aug 2013 | 12:00 am
Accurate positioning of the mitotic spindle is critical to ensure proper distribution of chromosomes during cell division. The small GTPase Ran, which regulates a variety of processes throughout the c...
Spatiotemporal dynamics of condensins I and II: evolutionary insights from the primitive red alga Cyanidioschyzon merolae 14 Aug 2013 | 12:00 am
Condensins are multisubunit complexes that play central roles in chromosome organization and segregation in eukaryotes. Many eukaryotic species have two different condensin complexes (condensins I and...
The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257 14 Aug 2013 | 12:00 am
Zona occludens 2 (ZO-2) has a dual localization. In confluent epithelia, ZO-2 is present at tight junctions (TJs), whereas in sparse proliferating cells it is also found at the nucleus. Previously we ...
Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs 14 Aug 2013 | 12:00 am
Adipocyte glucose uptake in response to insulin is essential for physiological glucose homeostasis: stimulation of adipocytes with insulin results in insertion of the glucose transporter GLUT4 into th...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15 14 Aug 2013 | 12:00 am
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in pa...
ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus 14 Aug 2013 | 12:00 am
Small GTPases of the ADP-ribosylation factor (ARF) family, except for ARF6, mainly localize to the Golgi apparatus, where they trigger formation of coated carrier vesicles. We recently showed that cla...
The PI3K/Akt1 pathway enhances steady-state levels of FANCL 14 Aug 2013 | 12:00 am
Fanconi anemia hematopoietic stem cells display poor self-renewal capacity when subjected to a variety of cellular stress. This phenotype raises the question of whether the Fanconi anemia proteins are...
Mechanisms of actin disassembly 31 Jul 2013 | 12:00 am
The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how c...
