Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium 1 Aug 2013 | 09:00 pm

In addition to its role as a physical barrier, the urothelium is considered to play an active role in mechanosensation. A key mechanism is the release of transient mediators that activate purinergic P...

Attenuation of lithium-induced natriuresis and kaliuresis in P2Y2 receptor knockout mice 1 Aug 2013 | 09:00 pm

Whole body knockout (KO) of the P2Y2 receptor (P2Y2R) results in enhanced vasopressin V2 receptor activity and increased renal Na+ conservation. We hypothesized that P2Y2R KO mice would be less sensit...

(Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H+-ATPase activity in MDCK.C11 collecting duct cells 1 Aug 2013 | 09:00 pm

Prorenin binding to the prorenin receptor [(P)RR] results in nonproteolytic activation of prorenin but also directly (i.e., independent of angiotensin generation) activates signal transduction cascade...

Civil, sensible, and constructive peer review in APS journals 1 Aug 2013 | 09:00 pm

Proximal tubular NHEs: sodium, protons and calcium? 1 Aug 2013 | 09:00 pm

Na+/H+ exchange activity in the apical membrane of the proximal tubule is fundamental to the reabsorption of Na+ and water from the filtrate. The role of this exchange process in bicarbonate reclamati...

Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular pe... 1 Aug 2013 | 09:00 pm

Systemic infusions of ANG II rapidly induce large, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor(s), ANG II generates reactive...

Class I histone deacetylase activity is required for proliferation of renal epithelial cells 1 Aug 2013 | 09:00 pm

The process of renal regeneration after acute kidney injury is thought to recapitulate renal development, and proliferation of renal proximal tubular cells (RPTCs) is a critical step in the regenerati...

Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells 1 Aug 2013 | 09:00 pm

Mitochondria are both a source and target of the actions of reactive oxygen species and possess a complex system of inter-related antioxidants that control redox signaling and protect against oxidativ...

Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease 1 Aug 2013 | 09:00 pm

Obesity-metabolic disorders (ObM) often accompany renal artery stenosis (RAS). We hypothesized that the coexistence of ObM and RAS magnifies inflammation and microvascular remodeling in the stenotic k...

The calcimimetic R-568 prevents podocyte loss in uninephrectomized ApoE-/- mice 1 Aug 2013 | 09:00 pm

Calcimimetics are indicated for secondary hyperparathyroidism in chronic kidney disease, and some data have suggested their protective role for progression of renal damage. We aimed to evaluate whethe...